More than 50% of children with a parent affected by severe mental illness may develop a mental health disorder by early adulthood. The FAMILY project is an innovative multimodal risk prediction framework that integrates genetics, epigenetics, neuroimaging, behavioral science, animal models, and artificial intelligence to better understand how mental illness is transmitted across generations. FAMILY investigates the complex interaction between genetic, environmental, epigenetic, and neurodevelopmental factors to identify both risk and resilience markers. The project also addresses ethical and social implications of risk prediction, supporting the development of personalized prevention strategies, early intervention tools, and family-centered mental healthcare guidelines.