Placental Health Risks Linked to Aromatic Hydrocarbon Exposure in Pregnancy
Higher exposure to environmental polycyclic aromatic hydrocarbons (PAHs) among women living in polluted areas has been linked to harmful effects on the human placenta. Key PAH biomarkers, including phenol and 1-hydroxypyrene, were associated with reduced placental hormone activity and decreased metabolic enzyme expression, indicating impaired placental function. It was also observed that lower expression of placental glutathione transferase and reduced placental phosphatase activity in placentas from polluted regions. In contrast, placentas from non-polluted areas showed significantly higher estrogen receptor activity and placental gonadotropin expression, highlighting the serious impact of industrial pollution on maternal and fetal health.
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