Scientists mapped the interaction network between Nipah virus and human proteins using affinity purification and mass spectrometry. The study highlights strong nuclear colocalization of viral W protein with PRP19 complex, altering p53 activity and host gene expression while its matrix protein M interacts with the DICER1–TARBP2 complex linked to RNA interference. 101 such human–Nipah virus protein interactions were studied that revealed how Nipah virus interferes with cellular pathways and highlight potential host targets and existing drugs that could guide the development of new antiviral therapies.