Category: Bulletins - Sci-Tech Bulletin

HEDD is an epigenetic drug database for drug discovery

HEDD Database: Advancing Epigenetic Drug Discovery, Cancer Research, and Precision Medicine Through Integrated Biomedical Data

The Human Epigenetic Drug Database (HEDD) is a comprehensive platform developed to organize and integrate epigenetic drug research data, including disease & drug information, clinical trials, molecular targets, high-throughput datasets, and drug-target structures. Data collected from major biomedical databases such as PubChem, DrugBank, GEO, and PDB has been used to create a centralized resource for scientists and clinicians. HEDD contains datasets on 64 epigenetic drugs, 1,606 targets, and 571 disease applications. The database supports flexible searches, 3D molecular visualization, and downloadable datasets, enabling advancements in drug discovery, cancer research, precision medicine, computational biology, and personalized therapeutic development.

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Ebola Virus VP24 and VP35 Interactions Reveal New Antiviral Drug Targets

Scientists have discovered the Ebola virus proteins VP24 and VP35 that forms complex and coordinates the formation of nucleocapsid assembly through the polymerization of nucleoprotein (NP) along the viral RNA genome. VP35 functions as a chaperone and replication cofactor, stabilizing a newly identified outer third monomeric layer of NP, while VP24 helps stabilize and condense the nucleocapsid structure. The study also revealed that the intrinsically disordered region and C-terminal domain of the outer NP layer act as a flexible tether linking the nucleocapsid to the viral matrix. These conserved protein interfaces are promising targets for broad-spectrum antiviral therapies.

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Myo-Inositol and Folic Acid: A Safe and Effective Treatment for PCOS-Related Infertility

An observational study provides strong evidence that myo-Inositol and folic acid supplements offer a safe and effective treatment approach for women with Polycystic Ovary Syndrome (PCOS). The research found that taking 2 grams of myo-inositol and 200 μg of folic acid twice daily for 2–3 months helps to restore ovulation and improve pregnancy rates in women struggling with PCOS-related infertility. The treatment significantly improves hormonal balance by lowering testosterone levels and increasing progesterone levels. Most importantly, no major side effects are observed, making myo-inositol and folic acid a practical, well-tolerated, and effective alternative to metformin for managing PCOS infertility.

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Umbilical Cord Mesenchymal Stem Cells is a promising therapy for Leukemia, GVHD, and Aplastic Anemia

Umbilical cord mesenchymal stem cells (UC-MSCs) are emerging as promising therapies for hematological diseases due to their high proliferation, low immunogenicity, and strong immunomodulatory properties. UC-MSCs support hematopoietic stem cell growth, reduce graft-versus-host disease (GVHD), and improve outcomes after stem cell transplantation. The therapy can potentially be applied in treating aplastic anemia, immune thrombocytopenia, and certain blood cancers. Their ability to regulate immune responses and target tumor cells makes them valuable in regenerative medicine and oncology.

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Ivermectin as a promising precision medicine against cancer

Ivermectin as a promising precision medicine against ovarian cancer

Ivermectin, widely used as an anti-parasitic drug, suppress ovarian cancer by targeting mRNA pathway of oncogene EIF4A3 which is responsible for the growth glioblastoma, hepatocellular carcinoma (liver cancer), pancreatic cancer, ovarian cancer, breast cancer, lung cancer, and bladder cancer. Ivermectin reduced cancer cell growth and migration while downregulating EIF4A3 and 116 related mRNAs. The findings suggest ivermectin has potential as a personalized ovarian cancer therapy and may support biomarker-driven prognosis and treatment monitoring.

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Mood Disorders and Impulsive Aggression Drive Youth Suicide Risk

Researchers have found that mood disorders and impulsive aggression are major predictors of suicidal behaviour. Impulsive aggression often precedes depression, increasing long-term suicide risk. The patients were studied for over 5 years, and it was found that children of parents who had attempted suicide are nearly five times more likely to attempt suicide themselves, even after accounting for mood disorders. The findings highlight the importance of early mental health screening, emotional regulation interventions, and family-based prevention strategies to reduce suicide risk among high-risk adolescents and young adults.

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Microbial Electrochemical Technology Treats Nitrate and Arsenic-Contaminated Groundwater

Microbial electrochemical technologies (METs) uses electro-bioremediation systems that can treat groundwater contaminated with nitrate and arsenite simultaneously. A continuous-flow bioelectrochemical reactor has been developed that reduces nitrate into harmless dinitrogen gas while oxidizing toxic arsenite into less harmful arsenate. The system can achieve high nitrate removal rates and over 95% arsenite oxidation efficiency under groundwater-like conditions. This works as the internal recirculation significantly improves treatment performance by enhancing mass transfers and microbial activity of denitrifying and arsenite-oxidizing bacteria like Sideroxydans sp and Achromobacter sp. Thus, electro-bioremediation as a sustainable, low-chemical, and energy-efficient solution for complex groundwater contamination challenges.

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Fetal Body MRI improves the diagnosis of fetal abnormalities

Fetal Body MRI Improves Prenatal Diagnosis and Neonatal Treatment

Fetal body MRI is improving prenatal diagnosis and neonatal treatment planning for congenital abnormalities. The motion-corrected 3D images obtained from MRI enhance the visualisation of fetal anatomy compared to traditional ultrasound alone and aids to determine atypical fetal position, reduced amniotic fluid volume, or high maternal body-mass index. Fetal MRI enables more accurate diagnosis, improves detection of complex abnormalities, supports surgical and delivery planning, and helps clinicians prepare for life-saving neonatal interventions such as airway management procedures, and improves outcomes for newborns with congenital conditions.

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Electrolyzed Water Is Transforming Hospital Disinfection and Hygiene Practices

Electrolyzed water (EW) is a cost-effective, eco-friendly disinfectant with strong antimicrobial and antibiofilm properties. Produced by electrolysis of salt and water, it generates hypochlorous acid (HOCl), which rapidly kills pathogens by damaging cell structures. Findings show significant effectiveness in wound care, hand hygiene, oral health, and surface disinfection, with fast microbial reduction and minimal toxicity. EW demonstrates strong practical potential for safer infection control in clinical and healthcare environments, although short shelf life of EW and reduced efficacy in organic matter can be addressed.

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Clove Extract Shows Powerful Anticancer Effects Across Multiple Cancer Types

A study demonstrated the anti-cancer potential of clove ethyl acetate extract across multiple cancers, including breast, ovary, cervix, liver, pancreas, and colon cancer. Although the key bioactive compound was identified as oleanolic acid, the extract displays greater effectiveness, suggesting synergistic interactions. The clove extract significantly inhibited tumour growth, induced cell cycle arrest, and promoted apoptosis by regulating key genes like p21, E2F1 and survivin. Clove extract thus shows promise as a natural or complementary cancer therapy, with low toxicity.

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