Plant-made proteins are emerging as a transformative platform for producing vaccines, antibodies, enzymes, and other biopharmaceuticals, offering a sustainable, cost-effective, and scalable alternative to conventional protein production systems. Advances in plant-based expression systems, genetic engineering, process optimization, and downstream manufacturing have significantly improved protein yield, quality, and scalability. Commercial successes such as Elelyso® and the Ebola therapy ZMapp demonstrate the growing maturity of molecular farming. Plant-made proteins have promising applications in rapid pandemic response, oral drug delivery through bioencapsulation, veterinary medicine, and affordable pharmaceutical production for developing countries.