Category: Health & Medicine - Sci-Tech Bulletin

Hibiscus Extract Stop Breast Cancer growth and Boost Treatment

Hibiscus extract has been studied for its ability to selectively kill breast cancer cells while sparing normal cells. The extract induced programmed cell death in triple-negative and estrogen-positive breast cancer cells in a dose-dependent manner. Moreover, it increases oxidative stress and disrupts mitochondrial function, thus enhancing the effectiveness of chemotherapies such as taxol and cisplatin at 50 folds lower drug doses. Thus, hibiscus can be potentially used as an adjuvant therapy for the long-term treatment of cancer and for improving the quality of life of patients.

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Boosting Adiponectin Naturally is the key to better Metabolism and Longevity

Adiponectin, classified as adipokine is a hormone produced by adipose tissue that acts as a cytokine to regulate glucose levels, lipid metabolism, and inflammation in the body. Higher levels of adiponectin have been studied to improve insulin sensitivity, promoting fat oxidation, and protecting organs such as the heart, liver, brain, and kidneys. Its pronounced role in regulating obesity, diabetes, cardiovascular disease and cancer makes it a highly valuable biomarker and a potential therapeutic target for monitoring the effectiveness of preventive and treatment interventions

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Multivitamins Improve Brain Health and Promote Healthy Aging

A randomised clinical trial carried on ~3500 patients for 3 years, shows that daily supplement of multivitamin like ‘Centrum Silver’ modestly improves cognitive abilities in older adults. The multivitamins are easily accessible, safe, low-cost strategy to maintain cognitive health in high-risk individuals suffering from lifestyle diseases. Daily supplements of multivitamins thus, has meaningful potential for population-level impact in promoting healthy cognitive aging.

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Suramin identified as a promising drug against Nipah Virus

Suramin, known for curing sleeping sickness and river blindness has been identified as a potent inhibitor of Nipah Virus (NiV) replication. At 100 µM, suramin completely abolishes the de novo RNA synthesis in NiV by binding within the NTP entry channel of the viral L protein, forming strong interactions with key conserved residues E291, K542, R551, K724, N833, and K893. By occupying this channel, the drug blocks the entry of nucleotide substrates into the active site, thereby preventing RNA synthesis n both biochemical assays and kidney cell–based systems.

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Drug VV116 New Hope in the Fight Against Nipah Virus

Scientist have identified the VV116 as a drug to control growth of Nipah virus and prevent development of acute encephalitis. At an effective dose of 400mg/kg in humans, the virus demonstrated favourable pharmacokinetics, minimal tissue damage and improved survival rates of 67%, VV116 is suggested as an effective oral therapeutic candidate against Nipah virus.

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Tecelra and MAGE-A4: A Safer, High-Affinity Adoptive T-Cell Immunotherapy

Tecelra, an affinity-enhanced MAGE-A4–specific TCR approved for its efficacy against metastatic synovial sarcoma with minimal off-target risk. The gene therapy showed strong antigen-specific cytokine release, effective tumor cell killing in 2D and 3D models, and dose-dependent tumor regression with complete survival in vivo with manageable alloreactivity and limited cross-reactivity.

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